Plz help Why might onset of the disorder prove irreversible?

A.
Onset of the disorder might prove irreversible because the nerves affected would be in the dysphagia center of the brain.
B.
The disorder might prove irreversible because of production of malformed proteins.
C.
The mutation causes a disruption in energy movement, which would prove irreversible due to paralysis.
D.
Continued production of misshapen ATP and transport proteins would be catastrophic to all body systems.