Chemistry, 22.07.2021 21:00, Conner4600
Different steps of the oxidative decarboxylation of pyruvate by the pyruvate dehydrogenase PDH complex are given. Place these five steps in the correct order. Note that thiamine pyrophosphate, TPP, is sometimes called thiamine diphosphate, TDP.
1. FADH2 is reoxidized to FAD reducing NAD* to NADH.
2. The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the acetyl group to the lipoamide.
3. Pyruvate reacts with TPP and is decarboxylated forming hydroxyethyl-TPP.
4. The lipoamide arm moves to the active site of E3 where the reduced lipoamide is oxidized by FAD forming the active lipoamide and FADH2.
5. The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide.
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Different steps of the oxidative decarboxylation of pyruvate by the pyruvate dehydrogenase PDH compl...
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