Sarin is a deadly nerve gas that was outlawed by the Chemical Weapons Convention of 1993. However, it has been used at various times as a weapon of mass destruction by terrorists, including a 1995 attack in the Toyko metro and a 2013 attack by the Syrian government on rebel forces during the Syrian civil war. Sarin is an acid fluoride and ester of methyl phosphonic acid. The S‑enantiomer is more active than the R enantiomer.
Sarin's biological effects are due to its reaction with a serine residue in the active site of acetylcholinesterase, an enzyme that is very important in nerve transmission. Select the true statement.
a. Fluorine is the leaving group in Sarin.
b. The active site amine reacts with Sarin.
c. Isopropoxide is the leaving group in Sarin.
d. Phosphine is the leaving group in Sarin.
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