Therapeutic drugs generally need to have some hydrophobic and hydrophilic components to be able to effectively reach their target organs and tissues given there are aqueous and nonaqueous parts of the body. The degree to which a compound is hydrophobic and hydrophilic can be determined by measuring its relative solubility in water and octanol, C8H17OH, and water. To do this, a sample of the compound is added to a mixture of water and octanol and mixed well. Water and octanol are immiscible so after the mixture settles, the concentration of the compound in water and the concentration of the compound in octanol is measured. The ratio of the concentrations is called the partition ratio:

The question is incomplete as some part is missing:

concentration in octanol Partition Ratio = concentration in water

a) What are the intermolecular forces of attraction between octanol molecules? Explain.

b) Which of the intermolecular forces of attraction identified in (a) account for most of the interactions between octanol molecules? Explain. Use the immiscibility in water and the data included in figures 1 and 2 as evidence to support your answer.

c) Would a compound with a partition coefficient less than one be more hydrophobic or more hydrophilic than one with a partition coefficient greater than 10? Explain.

d) Would nonane (figure 2) be more soluble in water or octanol? Explain.

e) Draw another structure for a compound with the same chemical formula as nonane (CH20) that has a lower boiling point. Explain.

f) Are any of the C atoms in the structure you drew for CH20 sp?hybridized? Explain.

Octanol Boiling point = 195°C Figure 2 Nonane (CH20) Boiling point = 151°C

1. The forces between octanol molecules would be attractive. These forces include Vanderwaal forces, H-bonds due to the presence of highly polar O-H group.

2. H-bonding ahould account for most of the attractive forces. The O-H bond should behave like and dipole, oxygen of one molecule attracts the hydrogen of the neighbouring molecule forming D-H...A links throughout (D stands for donor of H-Bond and A for acceptor for H-Bond).

3. Partition coefficient less than 1 will be more hydrophilic, generally drugs with low partition coefficients are regarded as hydrophilic. As parition coefficient of 10 mean more of the solute is dispersed in octanol as compared to water.

4. Nonane is non polar, so it would not dissolve in water. It follows the rule like dissolves like. Polar substances dissolve in polar solvents. 1-octanol is able to bind with water through hydrogen bonds thus its soluble in water but nonane doesn't. Nonane will forms a different layer from water.

5) no all carbons in 2-methyloctane are single bonded. Thus sp3 hybrid. A sp2 hybridised carbon would have a double bond C=C.

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it is a solid

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