Different steps of the oxidative decarboxylation of pyruvate by the pyruvate dehydrogenase PDH complex are given. Place these five steps in the correct order. Note that thiamine pyrophosphate, TPP , is sometimes called thiamine diphosphate, TDP .
---Pyruvate reacts with TPP and is decarboxylated, forming hydroxyethyl-TPP
---The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the acetyl group to the lipoamide.
---The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide.
--- the lipoamide arm moves to the active site of E3, where the reduced lipoamide is oxidized by FAD, forming the active lipoamide and the FADH2.
--- FADH2 is reoxidized to FAD reducing NAD+ to NADH
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Different steps of the oxidative decarboxylation of pyruvate by the pyruvate dehydrogenase PDH compl...
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