Two proteins interact to form a multimeric complex. When one of the proteins is mutated, there is a substantial loss of functional activity in the multimeric protein. This type of mutation is classified as:.1. hypomorphic2. amorphic3. hypermorphic4. dominant negative5. neomorphic

Explanation:

Mutation is the process in which sudden changes take place within the sequence of amino acids that causes different type of problems. On the basis of nature and conditions mutation can be classified as dominant negative, neomorphic and some others types. Dominant mutation is also called as antimorphic mutation and changes the functions of the  molecules that are proteins.

"among the transition metal elements, manganese and zinc have a slight lowering of electronegativities. the reason behind this is that the nuclear charges of these elements are slightly weaker than the other transition metal elements due to the way their valence electrons are filled up. both manganese and zinc have their valence electrons filled up to the 4th shell with 1 pair of electrons (4s2) completely occupying it. although the electrons in the 3rd shell (3d) are yet to be paired since the outer most shell is filled up, the ability of the nucleus to attract electrons is lessened. hence,   the electronegativity (or the ability to attract electrons) is lessened."