Which anticholinergic agent is sometimes used to manage motion sickness when delivered by transdermal patch?

Scopolamine.

Explanation:

Scopolamine is also known as hyoscine. It is an anticholinergic, oral topical drug which is used to manage, and prevent motion sickness, and acute treatment. It is must be taken to be effective before the onset of motion sickness.

The scopolamine is helps to prevent communication between the vomiting center which is present in the brain, and the nerve of the vestibule by blocking the action of acetylcholine (it is a chemical which nervous used to transmit massage to each other).