The second messenger cyclic amp (camp) is synthesized from atp by the activity of the enzyme adenylyl cyclase. cyclic amp, in turn, activates protein kinase a (pka), also called camp‑dependent protein kinase, which is responsible for most of the effects of camp within the cell. determine the correct steps in the activation of pka, and then place them in the correct order, starting after the adenylyl cyclase reaction.

Effect of rotenone and antimycin a on electron transfer rotenone, a toxic natural product from plants, strongly inhibits nadh dehydrogenase of insect and fish mitochondria. antimycin a, a toxic antibiotic, strongly inhibits the oxidation of ubiquinol. (a) explain why rotenone ingestion is lethal to some insect and fish species. (b) explain why antimycin a is a poison. (c) given that rotenone and antimycin a are equally effective in blocking their respective sites in the electron-transfer chain, which would be a more potent poison? explain.