the first reaction in glycolysis is the phosphorylation of glucose. one possible reaction might be:
pi + glucose ↔ glucose− 6−phosphate
this is a thermodynamically unfavorable process with ∆g' o = 3.3 kcal mol−1
a. in a liver cell at 370 c, the concentration of both phosphate and glucose are normally maintained at about 5 mm each. what would be the equilibrium concentration of glucose− 6−phosphate, if the 3 reaction proceeds as outlined above? does this reaction represent a reasonable metabolic step for the catabolism of glucose? explain why?
b. in principle, at least one way to increase the concentration of g6p is to drive the equilibrium to the right by increasing the intracellular concentrations of pi and/or glucose. assuming a fixed concentration of pi at 5.0 mm, how high would be the intracellular concentration of glucose have to be to give an equilibrium concentration of glucose−6−phosphate of 0.25 mm (the normal physiological concentration)? would this route be reasonable, given the maximum solubility of glucose is less than 1 m?
c. in fact, in vivo the reaction is coupled to atp hydrolysis (∆g' o = -30.5 kj mol−1 ) to give the overall reaction: atp + glucose ↔ glucose− 6−phosphate + adp write the two reactions which when coupled yield the above reaction. calculate ∆g' o and keq' for the coupled reaction.
d. if, in addition to coupling of phosphorylation reaction to atp hydrolysis, we also have in the liver cell 3 mm atp and 1 mm adp, what is the in vivo equilibrium concentration of glucose−6−phosphate?
Answers: 3
Chemistry, 22.06.2019 03:30, electrofy456
What diagram shows the ionic compound of magnesium oxide
Answers: 2
Chemistry, 22.06.2019 10:30, zayam1626
Great amounts of electromagnetic energy from our sun and other bodies in space travel through space. which is a logical conclusion about these electromagnetic waves? their energy must be very their frequency must be very low these waves can travel without a medium they only travel through a vacuum of space
Answers: 2
Chemistry, 22.06.2019 14:50, alexabbarker9781
How are evaporation and sublimation similar? a both involve the formation of a gas. b both release energy to the surroundings. c both take place throughout a solid. d both take place at the surface of a liquid.
Answers: 1
the first reaction in glycolysis is the phosphorylation of glucose. one possible reaction might be:...
Biology, 18.07.2019 16:30
Physics, 18.07.2019 16:30
Arts, 18.07.2019 16:30