Which of the following is true? which of the following is true? a buffer is most resistant to ph change when [acid] = [conjugate base] an effective buffer has very small absolute concentrations of acid and conjugate base. a buffer can not be destroyed by adding too much strong base. it can only be destroyed by adding too much strong acid. an effective buffer has a [base]/[acid] ratio in the range of 10 - 100. none of the above are true.