Approaches that can minimize biases in the design of a clinical trial are: question 5 options:
a. clearly define risk and outcome, with objective and preferably validated methods
b. standardize and blind data collection
c. select patients using rigorous criteria
d. all of the above

Xinhong company is considering replacing one of its manufacturing machines. the machine has a book value of $39,000 and a remaining useful life of 5 years, at which time its salvage value will be zero. it has a current market value of $49,000. variable manufacturing costs are $33,300 per year for this machine. information on two alternative replacement machines follows. alternative a alternative b cost $ 115,000 $ 117,000 variable manufacturing costs per year 22,900 10,100 1. calculate the total change in net income if alternative a and b is adopted. 2. should xinhong keep or replace its manufacturing machine