You join a laboratory to study muscle function. You decide to inhibit the pumping of Ca2+ into the sarcoplasmic reticulum to determine how excess cytosolic Ca2+ will affect muscle function. Which of the following strategies would be effective in blocking Ca2+ pumping?
Choose one:
A. block binding of ATP to the pump in the lumen of the sarcoplasmic reticulum
B. enhance the binding of ATP to the Ca2+ pump
C. block the phosphorylation of the conserved aspartate in the Ca2+ pump
D. block the hydrolysis of ATP to AMP by the Ca2+ pump
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