Hepatosplenomegaly refers to enlargement of the gallbladder enlargement of the liver and spleen softening of the liver and spleen enlargement kidney and spleen hardening of the kidney and spleen

Hepatosplenomegaly refers to the enlargement of the liver and the spleen. 
This is a disorder where both the spleen and liver swell beyond their normal size. This occurs due to an infection such as viral hepatitis or mononucleosis. it may be also a sign of lysosomal storage disorder which is a more serious condition. 

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