The first step in the replication of dna is catalyzed by the first step in the replication of dna is catalyzed by ligase helicase dna polymerase primase single-strand binding protein

The answer is helicase. This enzyme allows of the unzipping of the double helix DNA to form the replicating fork. They use ATP hydrolysis to break the hydrogen bonds between nucleotide bases. This comes before binding, on the DNA, by replication enzymes such as DNA Polymerase III.  

economic impact of malaria is estimated to cost africa $12 billion every year. this figure factors in costs of health care, absenteeism, days lost in education, decreased productivity due to brain damage from cerebral malaria, and loss of investment and tourism.

the tricuspid valve is present between right atrium and right ventricle