In organisms with large genomes, inversions are more likely to be tolerated if the breakpoints occur in:

The answer is telomeres. These are the regions at the end of the chromosomes that are composed of random repeats of nucleotide sequences. When the DNA is duplicated entirely by DNA polymerases such as during mitosis, the lengths of chromosomes reduce slightly by every duplication. This is due to the aspect of the lagging strands replication that is unable to be completed to the end of the chromosome. Therefore telomeres protect the chromosome from losing critical genes since mutations on telomeres will not affect the cell functionality.  

both anaerobic and aerobic respiration use glucose (or other carbohydrates), proteins and lipids to produce atp and nadh. cell uses those energy molecules, obtained from food and   breaks them down during the chemical reactions of respiration. in anaerobic respiration, nadh is regenerated to nad+ by enzymes lactate dehydrogenase (lactate is produced, e.g. in muscle cells) or by alcohol dehydrogenase where ethanol is produced (alcohol fermentation), while in aerobic respiration, electrons from nadh are deposited in the mitochondria to regenerate nad+ (electron transport chain. anaerobic respiration produces 2 atp per molecule of glucose compared to aerobic respiration where about 38 atp molecules are produced.

a physical change is being made.