Mastering biology why is a frameshift missense mutation more likely to have a severe effect on phenotype than a nucleotide-pair substitution missense mutation in the same protein?

When it is summer at the south pole, a. the northern hemisphere is tilted toward the sun. b. the southern hemisphere is tilted away from the sun. c. the northern hemisphere is tilted away from the sun. d. both the southern and northern hemispheres are tilted toward the sun.