Sickle-cell amenia is caused when a mutation results in the replacement of glutamate with valine. which type of mutation is observed here? a. chromosmal mutationb. frameshift mutationc. substitution mutation

it is either c or d and i know for sure it is not a or b

the principles and empirical processes of discovery and demonstration considered characteristic of or necessary for scientific investigation, generally involving the observation of phenomena, the formulation of a hypothesis concerning the phenomena, experimentation to test the hypothesis, and development of a conclusion that confirms, rejects, or modifies the hypothesis.