Some researchers suggest that poor regulation of the brain's may lead to panic attacks, which cause the limbic system to become overstimulated.

poor regulation of the brain's locus ceruleus may lead to panic attacks.

Locus ceruleus is a nucleus in the pons involved with physiological responses to stress and panic. When there is stress he responds by increasing norepinephrine (NE) secretion,  which is a critical regulator of numerous activities from stress response. Panic attacks result from alterations to NE.