"describe how prolonged immobilization results in muscle injury"

Rhabdomyolysis constitutes a common cause of acute renal failure and presents paramount interest. A large variety of causes with different pathogenetic mechanisms can involve skeletal muscles resulting in rhabdomyolysis with or without acute renal failure. Crush syndrome, one of the most common causes of rhabdomyolysis presents increased clinical interest, particularly in areas often involved by earthquakes, such as Greece and Turkey. Drug abusers are another sensitive group of young patients prone to rhabdomyolysis, which attracts the clinical interest of a variety of medical specialties. We herein review the evidence extracted from updated literature concerning the data related to pathogenetic mechanisms and pathophysiology as well as the management of this interesting syndrome. Keywords: Rhabdomyolysis, acute renal failure, myoglobin, crush syndrome The first case of the crush syndrome, which constitutes one of the main causes of rhabdomyolysis, was reported in Sicily in 1908, after an earthquake1,2. In 1930, in the Baltic area, an epidemic of myoglobinuria was observed due to consumption of contaminated fish. Interest in rhabdomyolysis and crash syndrome was stimulated during the World War II particularly after the bombing in London, where the victims developed acute renal failure and myoglobinuria1. Rhabdomyolysis is a rupture (lysis) of skeletal muscles due to drugs, toxins, inherited disorders, infections, trauma and compression3. Lysis of muscle cells releases toxic intracellular components in the systemic circulation which leads to electrolyte disturbances, hypovolemia, metabolic acidocis, coagulation defects and acute renal failure due to myoglobin4. The skeletal muscle consists of cylindrical myofibrils, which contain variant structural and contraction proteins. Actin and myosin, arranged in thin and thick filaments respectively, form the repeated functional units of contraction, the sarcomeres5. The sarcoplasmic reticulum constitutes an important cellular calcium storage. It is structurally connected to the t-tubules, that are formed by invaginations of the muscle cell plasma membrane, the sarcelemma, around every fibril (Figure 1). After the sarcelemma depolarization, the stimulation arrives, through the t-tubules junctions, at the sarcoplasmic reticulum, inducing the calcium ions release and triggering muscle contraction6.

Schools are being forced to embrace computers. unlike their "digital immigrant" teachers, these students are "digital natives", born into a world where technology is an integral part of everyday life. almost every student has access to a multitude of computers, laptops and tablet devices. it would be crazy to assume an assignment would  notbe written on computer in this day and age.many schools now have a 1-to-1 computer policy, and many districts and states in the united states have mandated computers or ipads across the state for every student,  including los angeles, the second largest school district in the country.but the thing is, when they tried it in la, it wasn't the success they hoped for. that's because the tablets weren't used as much as they expected. rather, it appeared there was a gap between the digital native's love of technology and their use of it in the classroom.this conflicted relationship with computers is also underscored by much of the literature on education. it is also highlighted in professional development and conferences such as  edutech.