White blood cells (wbcs) are more resistant to lysis than red blood cells (rbcs). when looking at a sample of blood for wbcs, what could you do to reduce interference from rbcs? white blood cells (wbcs) are more resistant to lysis than red blood cells (rbcs). when looking at a sample of blood for wbcs, what could you do to reduce interference from rbcs? mix the blood in an isotonic solution and allow the wbcs to float to the top. mix the blood in a salty solution to cause the rbcs to lyse. mix the blood in a hypotonic solution, which will cause the rbcs to lyse. mix the blood in a hypertonic solution, which will cause the rbcs to lyse.