3. Sickle cell anemia is caused by a genetic defect in coding for the amino acid sequence of hemoglobin, causing abnormal red blood cells. The blood of heterozygous persons appear normal, but when it is held under low oxygen concentration, the red blood cells become sickle shaped. A young man has a sister who died of sickle cell, and he is concerned about the possibility of the condition appearing in his children. When his blood is placed under low oxygen concentration the cells become sickled, but those of his wife do not. What is the probability of their children having the disease? How many of their children are likely to be carriers?

Mouse liver cells were homogenized and the homogenate subjected to equilibrium density-gradient centrifugation with sucrose gradients. fractions obtained from these gradients were assayed for marker molecules (i. e., molecules that are limited to specific organelles). the results of these assays are shown in the figure. the marker molecules have the following functions: cytochrome oxidase is an enzyme involved in the process by which atp is formed in the complete aerobic degradation of glucose or fatty acids; ribosomal rna forms part of the protein-synthesizing ribosomes; catalase catalyzes decomposition of hydrogen peroxide; acid phosphatase hydrolysis monophosphoric esters at acid ph; cytidylyltransferase is involved in phospholipid biosynthesis; and amino acid permease aids in transport of amino acids across membranes. a) name the marker molecule and give the number of the fraction that is most enriched for each of the following cell components: lysosomes; peroxisomes; mitochondria; plasma membrane; rough endoplasmic reticulum; smooth endoplasmic reticulum.