How can some large molecules and charged ions get through the cell membrane?

i believe the correct answer from the choices listed above is the first option. the scientists need to look at the   validity of data, claims, hypotheses, and observations before  developing an argument. they base their arguments on facts that are present and they make sure they have proofs. 

explanation:

every el niño cycle is different. every year.

1. the energy lost to disorder metabolism     -entropy

2. related to or possessing motion potential     -kinetic

3. all of the chemical reactions in an organism required for maintenance of the processes of life entropy     -metabolism

4. possible; ability to go into action or perform work kinetic     -potential

5. the study of energy and its transformations thermodynamics     -thermodynamics