A large protein that passes through the nuclear pore must have an appropriate A)sorting sequence, which typically contains the positively charged amino acids lysine and arginine. B)sorting sequence, which typically contains the hydrophobic amino acids leucine and isoleucine. C)sequence to interact with the nuclear fibrils. D)Ran-interacting protein domain. Multiple Choice

A)sorting sequence, which typically contains the positively charged amino acids lysine and arginine.

Explanation:

Protein sorting refers to the cellular process by which proteins are transported to their corresponding localizations both inside or outside the cell. A nuclear localization sequence (NLS) is a short amino acid signaling sequence that is able to mediate the transport of proteins into the nucleus. The proteins that are 'tagged' by an NLS sequence can pass through the nuclear envelope via nuclear pores. This sequence (NLS) is typically composed of protein motifs consisting of positively charged lysine (Lys) and arginine (Arg) amino acid residues, which are exposed on the protein surface. In consequence, the NLS sequence is recognized by the importin α/β heterodimer receptor, which transports the NLS-tagged protein into the nucleus. It has been shown that the deletion of the NLS sequence disrupts nuclear import, whereas the fusion of non-nuclear proteins with NLS sequences represents a useful strategy to introduce proteins into the nucleus.

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