Cystic fibrosis: autosomal and recessive; the most common lethal genetic disorder in US; 1/25 (4%) of Caucasians is a carrier; caused by a mutation on chromosome 7; the normal allele for this gene is involved in cellular chloride ion transport; the mutation results in a high concentration of extracellular chloride; characterized by a buildup of a secretion of thick mucus which accumulates in the lungs and digestive tract; if untreated, children with CF die at a young age
Hemophilia: sex-linked and recessive; missing one or more proteins necessary for normal blood clotting; when victims are cut, a firm clot is slow to form; bleeding in the muscles are joints are common and painful; 1/10,000 males are born with a form of this disorder
Duchenne muscular dystrophy: sex-linked and recessive; affects 1/3500 males born in US; missing an essential muscle protein called "dystrophin"; resulting in deteriorating muscles and a loss of coordination; victims rarely live past their early 20s
Huntington's disease: autosomal and dominant; this fatal disease begins to be expressed in middle age; a degenerative disease of the nervous system; loss of motor control progressing to total physical and mental incapability; results in certain and early death; individuals with this condition have a 50% chance of passing it onto their offspring
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