Blood type is determined by proteins. Blood type A has a different protein than blood type B. Blood type AB has both types of proteins and type o does not have either type of protein. When blood is transfused, the recipient's immune system will detect any
new or foreign proteins. The blood type proteins must be located:
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in the red blood cell nucleus.
Inside the red blood cell cytoplasm.
on the outer surface of the red blood cell membrane
in the nuclear membrane.