Enzymes play essential roles in many functions of cells, organs and organisms. The diagram below represents a hypothetical enzyme protein with 100 amino acids. The number scale indicates the position of each amino acid. Below the protein representation is an annotation that describes the function of the indicated amino acids in this protein. This enzyme is regulated by an allosteric inhibitor. Amino Acid position number>

0 10 20 30 40 50 60 70 80 90 100



I<>I I<>I
Allosteric Site Active Site

The questions are below.

Please organize your answers using the headings associated with each question below. To do so, simply copy the four questions and their subheadings into the answer space below and then type your answers to the parts of each question in alignment with its corresponding heading.

A. Identify an amino acid position for this enzyme where, if there were a point insertion mutation in the codon, the most likely effect on the enzyme would be neutral. Justify your answer with a brief description.

Justification:

B. What would be the likely effect on this enzyme’s activity if there were two separate deletion mutations and two insertion mutations and one substitution mutation in the codons for the amino acids between position 45 and 65? Justify your answer with a brief description.

Justification:

C. Where would a substitution mutation in the second base of a codon be least likely to have an effect on the function of the enzyme? Justify your answer with a brief description.

Justification:

D. What would be the likely effect on enzyme function if there were a substitution mutation in the first base of a codon for an amino acid at position 30? Justify your answer with a brief description.

Justification:

Mantle convection  is the slow  creepingmotion of earth's solid silicate  mantle  caused by  convection  currents carrying  heat from the interior  to the planet's surface.[1][2]  the earth's surface  lithosphere, which rides atop the  asthenosphere  (the two components of the  upper mantle), is divided into a number of  plates  that are continuously being created and consumed at their opposite  plate boundaries. accretion occurs as mantle is added to the growing edges of a plate, associated with  seafloor spreading. this hot added material cools down by  conduction  and  convection  of heat. at the consumption edges of the plate, the material has thermally contracted to become dense, and it sinks under its own weight in the process of  subduction  usually at an  ocean trench.[3]this subducted material sinks through the earth's interior. some subducted material appears to reach the lower mantle,[4]  while in other regions, this material is impeded from sinking further, possibly due to a phase transition from  spinel  to  silicate perovskiteand  magnesiowustite, an  endothermic reaction.[5]the subducted oceanic crust triggers  volcanism, although the basic mechanisms are varied. volcanism may occur due to processes that add buoyancy to partially melted mantle causing an upward flow due to a decrease in density of the partial melt.secondary forms of convection that may result in surface volcanism are postulated to occur as a consequence of intraplate extension[6]  and  mantle plumes.[7]it is because the mantle can convect that the  tectonic plates  are able to move around the earth's surface.[8]mantle convection seems to have been much more active during the  hadean  period, resulting in gravitational sorting of heavier molten  iron, and  nickel  elements and  sulphides  in the core, and lighter  silicate minerals  in the  mantle.

C. a mature ovule of a plant.