Roger Sperry's chemoaffinity hypothesis Group of answer choices is supported by the orderly reinnervation of the frog optic tectum by regenerating retinal ganglion cells. was based upon his discovery of cell adhesion molecules in the optic tectum. relies on the random innervation of the optic tectum by retinal neurons correctly predicted that each optic tectal neuron-retinal axon pair would have a unique molecular lock-and-key recognition signal.