Chromosomal mutations can have a variety of effects on individuals. klinefelter syndrome is a genetic disorder that occurs when a male has an extra copy of the x chromosome. males who have this disorder exhibit characteristics such as producing little or no facial hair, having a less muscular body than other males, and sterility. karyotype of klinefelter syndrome mc011-1.jpg which type of chromosomal mutation causes klinefelter syndrome? nondisjunction translocation deletion insertion