Parkinson's disease prevents the brain from properly sending motor signals to the consciously moved muscles of the body. this disease would therefore inhibit parts of the

Parkinson's I guess would inhibit parts of the synapses which produce or receive neurotransmitter substances such as dopamine or acetylcholine which are required to produces as EPSP excitatory post synaptic potential which is required for the propagation of nerve signals. so signals cant reach the conscious muscles as effectively causing the involuntary shaking of the muscles in people with Parkinson's

hope that helps

Iwould say overuse ( but not 100% sure ) in the u.s. we tend to overuse water by leaving it running, throwing it away, taking long showers, etc.