Sickle Cell Poster Analysis The 2nd column lists and compares the DNA sequence between a person with sickle cell disease and a person without sickle cell disease. After examining the two sequences, it is apparent that a 1 mutation has occurred. The 3rd column identifies the mRNA strand that formed in 2 (the first step of protein synthesis) as a result of the DNA code. ___3 molecules brought amino acids to the mRNA strand located on the 4 to form the 5 protein. This protein is different between an individual with sickle cell and a person without sickle cell in that the amino acid 6 was replaced with 7. This difference led to a difference in 8 for the hemoglobin molecule once it went to the ER and was folded into its proper configuration. The mutated protein has valine on its beta chain, which has a 9 R-group. This R-group is attracted to the nonpolar groove that forms on the 10 chain under ___11 oxygen conditions. As a result, the defective proteins clump together forming rods. These rods cause the red blood cell to 12. The medical implications of this is that a person will experience symptoms such as 13

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