The primary source of the specificity of enzymes is . The primary source of the specificity of enzymes is . their polarity, which matches that of their specific substrate their shape, which relates to the lock-and-key model their bonded transition metal, which is specific to the target substrate their delocalized electron cloud their locations within the cell

their shape, which relates to the lock-and-key model

Explanation:

Enzymes are biological catalysts that are proteinous in nature. Their proteinous nature implies that they are made of amino acids, which forms a three-dimensional shape that accounts for their functionality and specificity. This means that enzymes are substrate-specific because of their 3D shape.

The three-dimensional shape of an enzyme determines the kind of substrate it will bind to. Enzymes, generally, catalyze reactions by binding to a substrate at their active site. This binding follows a lock and key pattern or model. In a nutshell, the primary source of specificity of enzymes is attributed to their SHAPE, which relates to the lock-and-key model.