Hemophilia in humans is an X-linked recessive disease. A woman with hemophilia A marries an unaffected man whose father has hemophilia. What proportion of their
sons specifically and daughters will be expected to have hemophilia?

The following examples show how the hemophilia gene is inherited. It is important to note that one third of people with hemophilia have no family history of this disorder.

1. In this example, the mother is the carrier of the hemophilia gene and the father does not have hemophilia.

• There is a 50% chance that every male child will have hemophilia.

• There is a 50% chance that each daughter carries the hemophilia gene.

2. In this example, the father has hemophilia and the mother does not carry the hemophilia gene.

• All daughters will carry the hemophilia gene.

• Neither child will have hemophilia.

3. In this example, the father does not have hemophilia and the mother does not carry the hemophilia gene.

• None of the children (female or male) will have hemophilia or carry the gene.

Explanation:

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