g The primary digestive enzyme released by the stomach, as well as many of the digestive enzymes created and released by the pancreas, are initially released in their inactive form and must be activated after the fact. For one, explain how this activation occurs (and how it differs between the enzymes from these two organs), and for another, explain why this paradigm of releasing inactive enzymes is so important, physiologically.

The release of inactive form of enzyme is important because when the enzyme will active on its release it can digest the organs and glands from where it had been released to support the function of the enzyme only when it is required to be released and promote its functioning at the target site the enzyme is required to be released only in an inactive state.

Explanation:

Pepsin is a an enzyme secreted by the stomach cells in the inactive form that is called as pepsinogen. The function of the pepsinogen is to digest protein in the food. The activation of pepsin requires an acidic pH maintained by the hydrochloric acid in the gastric secretion of stomach. The   pancreatic cells secrete enzyme trypsinogen which is activated into trypsin when it enters into the duodenum of the small intestine by the enzyme enteropeptidase.