Why is a shell considered to be biotic?

A shell is considered as biotic (living) because it is a hard, rigid covering of many animals such as snail, sepia, pila, turtles, sea urchins. A shell is protective outer layer of these soft bodied animals.

enzyme active site and substrate specificity

enzymes bind with chemical reactants called substrates. there may be one or more substrates for each type of enzyme, depending on the particular chemical reaction. in some reactions, a single-reactant substrate is broken down into multiple products