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Which of the following is a difference between active transport and facilitated diffusion? view available hint(s)which of the following is a difference between active transport and facilitated diffusion? facilitated diffusion can move solutes against a concentration gradient, and active transport cannot. active transport involves transport proteins, and facilitated diffusion does not. facilitated diffusion involves transport proteins, and active transport does not. active transport requires the expenditure of cellular energy, and facilitated diffusion does not.