The concept of induced fit refers to the fact that a. Substrate binding may induce a conformational change in the enzyme, which them brings catalytic groups into proper orientation. b. When enzymes bind substrates, the substrates are bought into proximity to make a chemical reaction favorable. c. When a substrate binds to an enzyme, the enzyme induces a loss of water from the substrate. d. When a substrate binds to an enzyme, free energy is released due to non-covalent interactions.

Option A, Substrate binding may induce a conformational change in the enzyme, which them brings catalytic groups into proper orientation.

Explanation:

Induced fit concept refers to introduction of continuous change of enzyme conformation on substrate binding. This change in the shape of enzyme either inhibit or enhance the activity of enzyme. This makes the enzyme catalytic and hence lower the activation energy thereby increasing rate of reaction.

c. earths continental crust is thicker than its lithosphere.

because, the lithosphere is the outermost layer of the earth/ 100 km thick and is defined by its machanical properties.the lithosphere contains oceanic and continental crust that varies in age and thickness across locations and geologic time. the lithosphere is the coolest layer of the earth in terms of temperature. the term lithosphere should not be confused with the use of "geosphere" which is used to indicate all of earth systems, including the atmosphere, hydrosphere   and biosphere. the surface of the earth can be divided into the continental crust and the oceanic crust.   the continental crust is made mostly of granite while the oceanic crust is made of basalt. the average thickness of the continental crust is 25 miles and the average thickness of the oceanic crust is 5 miles.   three types of rock, igneous, sedimentary, and metamorphic, make up the surface of the earth. that's why 3 option is preferable.