Explain how cellular processes must be altered in stomach cancer cells compared with normal stomach cells to result in the different levels of SIRT3 expression observed.?

SIRT3 is a tumor suppressor gene that controls essential cellular processes including apoptosis, cell proliferation, survival and anoikis resistance

Explanation:

The Sirtuin-3 (SIRT3) gene encodes for a histone deacetylase enzyme involved in the epigenetic regulation of many essential genes, thereby controlling their expression levels. SIRT3 has a proapoptotic function that initiates apoptotic events in cancer cells. Moreover, SIRT3 also modulates cell proliferation and survival in both normal and tumorigenic cells by controlling the expression of genes that maintain Reactive oxygen species (ROS) at non-toxic levels. Finally, SIRT3 also mediates anoikis resistance (i.e., the resistance to detachment-induced cell death), thereby inhibiting tumorigenesis in cancer cells. It is for all these reasons that it has been proposed that SIRT3 represents a potential drug target for cancer therapy.

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