Which of the following mutations is likely to have the most detrimental impact on the stability a protein structure: Which of the following mutations is likely to have the most detrimental impact on the stability a protein structure: mutation of an Asn that is found on the surface of the protein to a Gln. mutation of a Leu that is found in the hydrophobic core to a Val. mutation of a Ser that is found on the surface of the protein to a Cys. mutation of a Glu that is found in the hydrophobic core to a Leu. mutation of an Arg that is forming an ionic bond with a nearby Glu to Lys.