Club foot is one of the most common congenital skeletal abnormalities, with a world-wide incidence of about 1 in 1000 births. Both genetic and nongenetic factors are thought to be responsible for club foot. C. A. Gurnett et al. identified a family in which club foot was inherited as an autosomal dominant trait with reduced penetrance. They discovered a mutation in the PITXI gene that caused club foot in this family. Through DNA testing, they determined that 11 people in the family carried the PITXI mutation, but only 8 of these people had club foot. What is the penetrance of the PITXI mutation in this family

0.727

Explanation:

Penetrance can be defined as a measure of the association between a genotype and phenotype. In medical genetics, the penetrance of a mutation leading to the disease state is the proportion of individuals carrying the mutation and showing disease symptoms associated with such mutation. For example, if a mutation leading to the disease state has a 90% of penetrance, it is expected that 9 of each 10 individuals carrying the mutation will develop the disease, while the remaining 10% will not develop the disease. In this case, 8 of each 11 individuals carrying the PITXI mutation show symptoms compatible with the disease, and therefore the penetrance is 8/11 = 0.727 (73%).

several tissues working together form an organ, and several organs together make up an organisms.

the group of cell that carries out special jobs are tissue.

the most common type of reef is the fringing reef. this type of reef grows seaward directly from the shore. they form borders along the shoreline and surrounding islands.