Biology, 19.02.2021 14:00, whackybrother24

Which small-scale mutation would be most likely to have the least negative effect on the function of a protein? A substitution of one base for another within the sequence
A base deletion near the start of a gene
A base deletion near the end of the coding sequence, but not in the terminator codon
A deletion of three bases near the start of the coding sequence, but not in the initiator codon

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Which small-scale mutation would be most likely to have the least negative effect on the function of...