increasing intracellular cAMP leads to smooth muscle relaxation by: Group of answer choices inhibiting IP3 channels, leading to decreased Ca2 in the sarcoplasm and reduced contraction. Increasing the relative activity of MLCP, leading to a decrease in tension. Activating K channels, increasing K leaking out of the cell which hyperpolarizes it and decreases the likelihood of Ca2 entry. Lower levels of MLCK activity, leading to decreased contraction.

1. Inhibiting IP3 channels, leading to decreased Ca2 in the sarcoplasm and reduced contraction.  

2. Increasing the relative activity of MLCP, leading to a decrease in tension.

3. Activating K channels, increasing K leaking out of the cell which hyperpolarizes it and decreases the likelihood of Ca2 entry.

Explanation

In smooth muscle, cyclic AMP (cAMP) mediates relaxation because cAMP inhibits a specific kinase required for myosin light chain protein (MLCP) phosphorylation, thereby triggering contraction in the smooth muscles. It has been shown that cAMP inhibits 1,4,5-trisphosphate (IP3)-dependent calcium ions (Ca 2+) release by activation of the cGMP-dependent protein kinase (PKG). PKG proteins act to modulate Ca2+ oscillations by stimulating sarcoplasmic Ca2+-ATPase membrane proteins, increasing Ca2+ in the sarcoplasmic reticulum stores and Ca2+ efflux from the cells, and activate voltage-gated potassium (K) channels, thereby leading to membrane hyperpolarization and reducing Ca2+ entry through Ca2+ channels.

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