Chromosomal mutations are changes in the normal structure or number of chromosomes. Changes in chromosome structure can result from errors in meiosis or from exposure to radiation or other damaging agents. Certain changes in chromosome number can result from nondisjunction during either meiosis or mitosis. Both structural mutations and nondisjunction can play a role in trisomy 21, commonly known as Down syndrome.

Yes.

Explanation:

Yes, both structural mutations and nondisjunction can play an important role in trisomy 21 which also called down syndrome. In this type of syndrome, extra copy of chromosomes is present in the cell. Down syndrome is a genetic disorder that causes various defects in the children such as learning problems, facial features, vision and hearing problems.

the framers of the constitution insisted that federal judges be nominated instead of elected due to their desire to have judges above the shifting whims of the masses.

the hope, whether achieved or not, was that federal judges would only be beholden to the law and that by not having judges be elected, they would be protected if that law dictated an outcome that ran counter to popular opinion.