H H II II
threonine - proline -N-C-0
lys
CH2 o
1
CH2 - C OH
glutamic acid
Normal
hemoglobin
Amino acid
substitution
H н но
II II
threonine-proline —N-C-0-lys
H3C - CH - CH3
valine
Sickle cell
hemoglobin
1. What is the difference between the normal hemoglobin and sickle cell hemoglobin?
2. What portion of the normal hemoglobin is identical to the sickle cell hemoglobin?
3. Write down two questions that you have about each of the hemoglobin based on your observations.