Help me please its due in a hour

The correct answer is - in the sickle-cell hemoglobin is the replacement of glutamic acid with valine in the β-globin amino acid chain.

Explanation:

Sickle cell anemia has a mutant gene in which that produces has valine amino acid instead of glutamate in the hemoglobin protein. In the given question the structure of the protein has only one difference that is the replacement of the glutamic acid in normal hemoglobin to valine in the β-globin amino acid chain in the mutant protein.

Valine 6 (beta chain) binds to a different hydrophobic patch (on the alpha chain and causes the disease in sickle cell anemia cases.

step 1: initiation

initiation is the beginning of transcription. it occurs when the enzyme rna polymerase binds to a region of a gene called the promoter. this signals the dna to unwind so the enzyme can ‘‘read’’ the bases in one of the dna strands. the enzyme is now ready to make a strand of mrna with a complementary sequence of bases.

step 2: elongation

elongation is the addition of nucleotides to the mrna strand. rna polymerase reads the unwound dna strand and builds the mrna molecule, using complementary base pairs. there is a brief time during this process when the newly formed rna is bound to the unwound dna. during this process, an adenine (a) in the dna binds to an uracil (u) in the rna.

step 3: termination

termination is the ending of transcription, and occurs when rna polymerase crosses a stop (termination) sequence in the gene. the mrna strand is complete, and it detaches from dna.