The toxin produced by the intestinal bacterium Vibrio cholerae induces excessive diarrhea by stimulating the excretion of NaCl and large amounts of water into the intestine. The mechanism by which cholera toxin acts is ADP ribosylation of: a. the GTP-bound form of Gai, locking it in the active conformation. b. the GDP-bound form of Gas, locking it in the inactive conformation. c. the GTP-bound form of Gas, locking it in the active conformation. d. Gaq, inhibiting its GTPase activity. e. Gai, decreasing its affinity for GDP.
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