Jacob argued that enzymes are not reusable and function to slow down the rate of reactions. Which statements show why Jacob's argument is incorrect? Select all that apply.

A
Enzymes are catalysts that speed up chemical reactions.

B
Enzymes increase the activation energy that is required for chemical reactions.

C
Enzymes are changed by the reaction and can be reused.

D
Enzymes are specific to the substrate to which they bind and can be reused.

E
All enzymes act on different reactions and by increasing the rate of the reaction.