Explain Why is there a net gain of onlý two ATP molecules in the glycolysis of one six-carbon glucose?

While 4 molecules of ATP are produced in total, 2 were used to convert glucose to the reactive fructose-1,6-bisphosphate

Thus, 4 ATP- 2ATP= 2ATP

Explanation:

In the cytoplasm, cellular respiration starts, where glucose is broken down for energy production. in the presence of oxygen, energy is produced through aerobic respiration, while in an oxygen-deprived environment, anaerobic respiration can be carried out.

Glucose is a relatively stable molecule, thus in order for the pyruvate-producing reaction to occur, the molecule undergoes phosphorylation through the addition of high energy phosphate groups to drive the reaction forward.

Pyruvate is generated through glycolysis in the cytoplasm-it is oxidized to form acetyl CoA in aeroboc respration also used in fermentation (anaerobic respiration) as an electron acceptor.

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