Histones are small proteins with a strong positive charge at physiological pH. They are found in the nuclei of eukaryotic cells and package DNA into nucleosomes, the fundamental structural units of chromatin. Based only on this description, what two forms of chromatography could you use, one after the other, to separate histones from other cellular proteins? Explain your reasoning.
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Histones are small proteins with a strong positive charge at physiological pH. They are found in the...
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