James has been diagnosed with Huntington's disease, a disease that develops when an individual has at least one dominant allele. James is married to Ava who does not have the disease. If James and Ava have a child, what is the probability that child will develop Huntington's disease? (Hint: There are two possible probabilities, you will need to provide both.) You MUST show both Punnett Squares in order to receive credit for this question!

See the answer below

Explanation:

First, let us assume that the allele for Huntington's disease is represented by H. An affected person would have HH or Hh gentoype while an unaffected person would be hh.

The genotype of James is either HH or Hh because he is affected for the disease while that of Ava would be hh because she is unaffected.

If James is HH:

            HH    x    hh

        Hh   Hh   Hh   Hh

All their offspring would have Hh genotype and hence be affected for the disease. Hence, if James and Ava have a child, the probability that the child will develop Huntington's disease is 100%.

If James is Hh:

   Hh    x    hh

  Hh   Hh   hh   hh

Hence, in this case, the probability of the child having the disease is 50%

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