2. What influence does the FBP1 protein have on the cell cycle and how can this proliferate the cancer

FBP1 promotes cancer by accelerating the transition of cell cycle from G1 to S and G2 stages

Explanation:

The far-upstream element (Fuse)-binding protein 1(FBP1) is an oncoprotein that is overexpressed in different types of cancers such as, for example, hepatocellular carcinoma, ovarian cancer, etc. It is known that FBP1 binds to the tumor suppressor gene p53 and thus suppresses its transcription. Moreover, in ovarian cancer, it has been shown that the inactivation or 'knockdown' of FBP1 inhibits cell cycle transition from G1 (the first phase of the cell cycle during cell division) to S and G2 phase. The cyclin D1/E and c-Myc proteins which are required for the progression of cells through the cell cycle were found to be inhibited in FBP1-knockdown cells.